M-Nisoldipine

M-Nisoldipine (KR-1008) is a dihydropyridine calcium antagonist that can significantly increase cardiac output and heart index, significantly reduce the negative inotropic effect on the myocardium, and has a relatively high selectivity for the thoracic aorta. m-Nisoldipine can be used in the research of cardiovascular diseases[1].

Product Specifications

CAS Number

[113578-26-0]

Product Name Alternative

KR-1008

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/m-nisoldipine.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=C(C)NC(C)=C(C(OCC(C)C)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OC

Molecular Formula

C20H24N2O6

Molecular Weight

388.41

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

References & Citations

[1]Yang C, et al. Thermodynamic stability analysis of m-nisoldipine polymorphs[J]. The Journal of Chemical Thermodynamics, 2013, 58: 300-306.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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