ALV1
ALV1 is a molecular glue degrader for Ikaros (IKZF1) and Helios (IKZF2) with DC50 of 2.5 nM and 10.3 nM respectively. ALV1 bind CRBN with an IC50 of 0.55 μM, and induces CRBN-Helios dimerization. ALV1 can be used to study the properties and functions of regulatory T cells[1].
Product Specifications
CAS Number
[2438124-79-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
IKZF Family; Interleukin Related; Ligands for E3 Ligase; Molecular Glues
Type
Reference compound
Related Pathways
Immunology/Inflammation; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/alv1.html
Purity
98.62
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C)C(Cl)=C1)CCC2=CC=CC(NC3=CC(N(C(CC4)C(NC4=O)=O)C3=O)=O)=C2
Molecular Formula
C25H23ClN4O5
Molecular Weight
494.93
Precautions
H302, H315, H319, H335
References & Citations
[1]Eric S Wang, et al. Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 2021 Jun;17 (6) :711-717.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
Cereblon; IKZF1; IKZF2
Available Sizes
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