(R) -Methanandamide

(R) -Methanandamide (AM-356), an analog of the endocannabinoid ligand Anandamide, is a potent CB1 agonist with a Ki of 20 nM. (R) -Methanandamide also activates vanilloid (TRPV1) receptors[1][2].

Product Specifications

CAS Number

[157182-49-5]

Product Name Alternative

AM-356

UNSPSC

12352211

Hazard Statement

H225, H315, H319, H335

Target

Cannabinoid Receptor; TRP Channel

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/r-methanandamide.html

Concentration

10mM

Purity

99.61

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC(N[C@H](C)CO)=O

Molecular Formula

C23H39NO2

Molecular Weight

361.56

Precautions

H225, H315, H319, H335

References & Citations

[1]V Abadji, et al. (R) -methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability. J Med Chem. 1994 Jun 10;37 (12) :1889-93.|[2]M J M Fischer, et al. Cannabinoid and vanilloid effects of R (+) -methanandamide in the hemisected meningeal preparation. Cephalalgia. 2007 May;27 (5) :422-8.