TFAP
TFAP is a selective cyclooxygenase-1 (COX-1) inhibitor, with an IC50 of 0.8 μM.
Product Specifications
CAS Number
[1011244-68-0]
Product Name Alternative
N- (5-Aminopyridin-2-yl) -4- (trifluoromethyl) benzamide
UNSPSC
12352005
Hazard Statement
H302
Target
COX; Endogenous Metabolite
Type
Natural Products
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/TFAP.html
Purity
99.98
Solubility
DMSO : ≥ 155 mg/mL
Smiles
O=C(NC1=NC=C(N)C=C1)C2=CC=C(C(F)(F)F)C=C2
Molecular Formula
C13H10F3N3O
Molecular Weight
281.23
Precautions
H302
References & Citations
[1]Kakuta H, et al. Identification of urine metabolites of TFAP, a cyclooxygenase-1 inhibitor. Bioorg Med Chem Lett. 2010 Mar 15;20 (6) :1840-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
COX-1
Available Sizes
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