Aspirin

Aspirin (Acetylsalicylic acid) is an orally active, potent and irreversible inhibitor of cyclooxygenase COX-1 and COX-2, with IC50 values of 5 and 210 μg/mL, respectively. Aspirin induces apoptosis. Aspirin inhibits the activation of NF-κB. Aspirin also inhibits platelet prostaglandin synthetase, and can prevent coronary artery and cerebrovascular thrombosis[1][2][3][4][5][6].

Product Specifications

CAS Number

[50-78-2]

Product Name Alternative

Acetylsalicylic acid; ASA

UNSPSC

12352005

Hazard Statement

H302

Target

Apoptosis; Autophagy; Caspase; COX; Mitophagy; NF-κB; p38 MAPK; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-anti-virus

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/aspirin.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 3.12 mg/mL (ultrasonic; warming; heat to 37°C)

Smiles

OC(C1=C(OC(C)=O)C=CC=C1)=O

Molecular Formula

C9H8O4

Molecular Weight

180.16

Precautions

H302

References & Citations

[1]Mitchell JA, et al. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90 (24) :11693-7.|[2]Wu KK, et al. Aspirin and other cyclooxygenase inhibitors: new therapeutic insights. Semin Vasc Med. 2003 May;3 (2) :107-12.|[3]Kopp E, et al. Inhibition of NF-kappa B by sodium salicylate and aspirin. Science. 1994 Aug 12;265 (5174) :956-9.|[4]Blanco FJ, et al. Effect of antiinflammatory drugs on COX-1 and COX-2 activity in human articular chondrocytes. J Rheumatol. 1999 Jun;26 (6) :1366-73.|[5]Burch JW, et al. Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest. 1978 Feb;61 (2) :314-9.|[6]Elwood PC, et al. Aspirin, salicylates, and cancer. Lancet. 2009 Apr 11;373 (9671) :1301-9.|[7]Loux JJ, DePalma PD, Yankell SL. Antipyretic testing of aspirin in rats. Toxicol Appl Pharmacol. 1972 Aug;22 (4) :672-5.|[8]Yomna I Mahmoud, et al. Spirulina ameliorates aspirin-induced gastric ulcer in albino mice by alleviating oxidative stress and inflammation. Biomed Pharmacother. 2019.|[9]Zhongzhi Wang, et al. Protective Effects of Ginger against Aspirin-Induced Gastric Ulcers in Rats. Yonago Acta Med. 2011, 54, 1.