Anti-Cytokine Receptor-like Factor 2 Antibody

Mouse Monoclonal Antibody specific to Cytokine Receptor-Like Factor 2

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Cytokine receptor-like 2, IL-XR, Thymic stromal lymphopoietin protein receptor, TSLP receptor

Gene Name

CRLF2

NCBI Gene ID

UniProt

Q9HC73

Cellular Locus

[Isoform 1]: Cell membrane, Single-pass type I membrane protein

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human TSLPR- Fc fusion protein. Accession no. Q9HC73.

Target Antigen

Cytokine receptor-like factor 2

Target

Cytokine Receptor-like Factor 2

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, IHC, ELISA

Field of Research

Growth Factors, Cytokines, Receptors

Purification Method

Purified by Protein A affinity chromatography

Dilution

Reconstitute lyophilized antibody using ultrapure to a final concentration no less than 100 ug/mL. Reconstitution with PBS or Tris buffer is acceptable if required. Protein carrier, biocide or cryopreservative can be added as needed. Aliquot and store at -20C for longterm storage. Dilute immediately prior to use.

Format

Purified

Form

Lyophilized

Buffer

Tris Buffer

Function

Receptor for thymic stromal lymphopoietin (TSLP). Forms a functional complex with TSLP and IL7R which is capable of stimulating cell proliferation through activation of STAT3 and STAT5. Also activates JAK2 (By similarity). Implicated in the development of the hematopoietic system. {PubMed:11418668}.

Additionnal Information

ELISA: use at 0.05-0.10ug/ml. Immunoblotting: use at 0.5-1ug/ml. A band of ~42kDa is detected. Immunohistochemistry: Formalin-fixed, paraffin-embedded tissue. Use at 1- 10ug/ml. These are recommended concentrations. Enduser should determine optimal concentrations for their applications.

Storage Conditions

This product is stable for at least one (1) year at -20°C to -70°C. Reconstituted product should be stored in appropriate aliquots to avoid repeated freeze-thaw cycles.

Specificity

This antibody reacts with human TSLPR.

Formulation

Lyophilized, 0.1M Tris, 0.1M glycine, 2% sucrose, 1mg/ml.

Target Background

Cytokine Receptor-like Factor 2, also known as thymic stromal lymphopoietin protein receptor (TSLPR), is the product of the CRLF2 gene. The protein encoded by this gene is a receptor for thymic stromal lymphopoietin (TSLP). Together with the interleukin 7 receptor (IL7R), the encoded protein and TSLP activate STAT3, STAT5, and JAK2 pathways, which control processes such as cell proliferation and development of the hematopoietic system. Two transcript variants encoding different isoforms have been found for this gene.

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