Fosphenytoin (disodium)

Fosphenytoin sodium is a phenytoin proagent with similar anticonvulsant properties. Its main mechanism is to block frequency-dependent, use-dependent and voltage-dependent neuronal sodium channels, and therefore limit repetitive firing of action potentials.

Product Specifications

CAS Number

[92134-98-0]

UNSPSC

12352005

Hazard Statement

H301, H312, H330, H410

Target

Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Fosphenytoin_disodium.html

Purity

99.81

Solubility

H2O : ≥ 100 mg/mL

Smiles

O=C1N(COP(O[Na])(O[Na])=O)C(C(C2=CC=CC=C2)(C3=CC=CC=C3)N1)=O

Molecular Formula

C16H13N2Na2O6P

Molecular Weight

406.24

Precautions

H301, H312, H330, H410

References & Citations

[1]Chan SA, et al. Fosphenytoin reduces hippocampal neuronal damage in rat following transient global ischemia. Acta Neurochir (Wien) . 1998;140 (2) :175-80.|[2]Loscher W, et al. Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. Epilepsy Res. 1998 Mar;30 (1) :69-76.