Stavudine

Stavudine (d4T) is an orally active nucleoside reverse transcriptase inhibitor (NRTI) . Stavudine has activity against HIV-1 and HIV-2. Stavudine also inhibits the replication of mitochondrial DNA (mtDNA) . Stavudine reduces NLRP3 inflammasome activation and modulates Amyloid-β autophagy. Stavudine induces apoptosis[1][2][3][4].

Product Specifications

CAS Number

[3056-17-5]

Product Name Alternative

D4T

UNSPSC

12352005

Hazard Statement

H341, H373

Target

Apoptosis; Autophagy; HIV; NOD-like Receptor (NLR) ; Nucleoside Antimetabolite/Analog; Reverse Transcriptase

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/stavudine.html

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)

Smiles

OC[C@H]1O[C@@H](N2C=C(C)C(NC2=O)=O)C=C1

Molecular Formula

C10H12N2O4

Molecular Weight

224.22

Precautions

H341, H373

References & Citations

[1]Moyle GJ, et al. The role of stavudine in the management of adults with HIV infection. Antivir Ther. 1997;2 (4) :207-218.|[2]Riddler SA, et al. Antiretroviral activity of stavudine (2',3'-didehydro-3'-deoxythymidine, D4T) . Antiviral Res. 1995;27 (3) :189-203.|[3]La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72 (2) :401-412.|[4]Ferraresi R, et al. Protective effect of acetyl-L-carnitine against oxidative stress induced by antiretroviral drugs. FEBS Lett. 2006;580 (28-29) :6612-6616.|[5]Anissa Igoudjil, et al. High doses of stavudine induce fat wasting and mild liver damage without impairing mitochondrial respiration in mice. Antivir Ther. 2007;12 (3) :389-400.