FRAX486

FRAX486 is a p21-activated kinase (PAK) inhibitor with IC50s of 14, 33 and 39 nM for PAK1, PAK2 and PAK3, respectively.

Product Specifications

CAS Number

[1232030-35-1]

UNSPSC

12352005

Hazard Statement

H302

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/FRAX486.html

Purity

98.10

Solubility

DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=CC(NC2=NC=C3C(N(CC)C(C(C4=CC=C(Cl)C=C4Cl)=C3)=O)=N2)=CC=C1N5CCNCC5

Molecular Formula

C25H23Cl2FN6O

Molecular Weight

513.39

Precautions

H302

References & Citations

[1]Wang Y, et al. P21-Activated Kinase Inhibitors FRAX486 and IPA3: Inhibition of Prostate Stromal Cell Growth and Effects on Smooth Muscle Contraction in the Human Prostate. PLoS One. 2016 Apr 12;11 (4) :e0153312.|[2]Hayashi-Takagi A, et al. PAKs inhibitors ameliorate schizophrenia-associated dendritic spine deterioration in vitro and in vivo during late adolescence. Proc Natl Acad Sci U S A. 2014 Apr 29;111 (17) :6461-6.