Gentamicin C1a

Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].

Product Specifications

CAS Number

[26098-04-4]

UNSPSC

12352005

Hazard Statement

H301, H311, H331, H341

Target

Antibiotic; Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/gentamicin-c1a.html

Purity

98.0

Solubility

H2O : 250 mg/mL (ultrasonic)

Smiles

O[C@@H]([C@@H]([C@H](C[C@H]1N)N)O[C@H]2O[C@@H](CC[C@H]2N)CN)[C@H]1O[C@@H]3[C@@H]([C@H]([C@@](O)(CO3)C)NC)O

Molecular Formula

C19H39N5O7

Molecular Weight

449.54

Precautions

H301, H311, H331, H341

References & Citations

[1]Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168 (5) :263-7. |[2]Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9 (1) :2410. |[3]Isoherranen N, et al. Pharmacokinetics of gentamicin C (1), C (1a), and C (2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44 (6) :1443-7.