Sumanirole (maleate)
Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. Sumanirole plays an important role in the research of Parkinson's disease and restless leg syndrome[1].
Product Specifications
CAS Number
179386-44-8
Product Name Alternative
U-95666E; PNU-95666
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Sumanirole-maleate.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)
Smiles
O=C1NC2=C3N1C[C@H](NC)CC3=CC=C2.O=C(/C=C\C(O)=O)O
Molecular Formula
C15H17N3O5
Molecular Weight
319.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E from
 D-Phenylalanine Using a Sequential Oxidative Cyclization
 Strategy. J. Org. Chem. 1997, 62, 6582-6587
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
D2 Receptor
Available Sizes
Frequently Asked Questions
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