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Sumanirole (maleate)

Sumanirole maleate (U-95666E; PNU-95666E) is a highly selective D2 receptor full agonist with an ED50 of about 46 nM. Sumanirole plays an important role in the research of Parkinson's disease and restless leg syndrome[1].

Product Specifications

CAS Number

[179386-44-8]

Product Name Alternative

U-95666E; PNU-95666

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dopamine Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Sumanirole-maleate.html

Purity

99.78

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : 10 mg/mL (ultrasonic)

Smiles

O=C1NC2=C3N1C[C@H](NC)CC3=CC=C2.O=C(/C=C\C(O)=O)O

Molecular Formula

C15H17N3O5

Molecular Weight

319.31

Precautions

H302, H315, H319, H335

References & Citations

[1]Arthur G. Romero, et al. Synthesis of the Selective D2 Receptor Agonist PNU-95666E from
 D-Phenylalanine Using a Sequential Oxidative Cyclization
 Strategy. J. Org. Chem. 1997, 62, 6582-6587

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

D2 Receptor

Available Sizes

Curated Selection

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