Mutant EGFR inhibitor
Mutant EGFR inhibitor (Example 25) is a potent mutant EGFR inhibitor. Mutant EGFR inhibitor inhibits FGFRWT with an IC50 of 0.41 nM. Mutant EGFR inhibitor inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M. Mutant EGFR inhibitor can be used for the study of diseases mediated by EGFR (particularly cancers) [1].
Product Specifications
CAS Number
[1421373-62-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mutant-egfr-inhibitor.html
Purity
99.40
Solubility
DMSO : ≥ 50 mg/mL
Smiles
C=CC(NC1=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C(OC)C=C1N(CCN(C)C)C)=O
Molecular Formula
C27H30ClN7O2
Molecular Weight
520.03
Precautions
H302, H315, H319, H335
References & Citations
[1]Sam Butterworth, et al, 2 - (2, 4, 5 - substituted -anilino) pyrimidine derivatives as egfr modulators useful for treating cancer. WO2013014448A1
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1
Available Sizes
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