GW604714X

GW604714X is a potent inhibitor of mitochondrial respiration supported by pyruvate but not other substrates. GW604714X is a highly specific mitochondrial pyruvate carrier (MPC) inhibitor with a Ki [1].

Product Specifications

CAS Number

[853953-65-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Mitochondrial Metabolism

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gw604714x.html

Purity

98.49

Solubility

DMF : 5.26 mg/mL (ultrasonic; warming)

Smiles

O=C(NC/1=O)SC1=C/C2=CC(C3=NC(N4CCN(C(C)=O)CC4)=CC=C3[N+]([O-])=O)=CC=C2F

Molecular Formula

C21H18FN5O5S

Molecular Weight

471.46

Precautions

H302, H315, H319, H335

References & Citations

[1]John C W Hildyard, et al. Identification and characterisation of a new class of highly specific and potent inhibitors of the mitochondrial pyruvate carrier. Biochim Biophys Acta. Apr-May 2005;1707 (2-3) :221-30.|[2]Allen K. Bourdon, et al. Alzheimer's and Parkinson's Disease Novel Therapeutic Target: The Mitochondrial Pyruvate Carrier - Ligand Docking to Screen Natural Compounds Related to Classic Inhibitors. DOI:10.4018/IJKDB.2017070104