CAD031
CAD031 is an orally active AMPK/ACC1 signaling pathway activator and a derivative of the Alzheimer's disease (AD) targeted agent J147 (more active than J147 in human neural stem cell assays). CAD031 can cross the blood-brain barrier, activate AMPK and inhibit ACC1, thereby increasing ac-CoA levels, improving mitochondrial function and reducing free fatty acid synthesis. CAD031 has neuroprotective, neurogenesis-promoting and memory-improving activities and can be used in the study of Alzheimer's disease and aging-related neurodegenerative diseases. CAD031 effectively enhances the memory of mice, improves dendritic structure, and stimulates cell division in the germinal zone of the brain of elderly mice[1][2][3].
Product Specifications
CAS Number
2071209-49-7
UNSPSC
12352005
Target
Acetyl-CoA Carboxylase; AMPK
Type
Reference compound
Related Pathways
Epigenetics; Metabolic Enzyme/Protease; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cad031.html
Purity
99.39
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC(F)(F)F)=C2)C(F)(F)F
Molecular Formula
C18H14F6N2O2
Molecular Weight
404.31
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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