TP0427736 (hydrochloride)

TP0427736 hydrochloride is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50=836 nM) . TP0427736 hydrochloride also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. TP0427736 hydrochloride can be used for the research of androgenic alopecia (AGA) [1].

Product Specifications

CAS Number

[2459963-17-6]

Product Name Alternative

BAW2881

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

TGF-β Receptor

Type

Reference compound

Related Pathways

TGF-beta/Smad

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Assay Protocol

https://www.medchemexpress.com/tp0427736-hydrochloride.html

Purity

99.22

Solubility

DMSO : 2 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 3.33 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CSC(C2=C(C3=CC=C4N=CSC4=C3)N=CN2)=N1.[H]Cl

Molecular Formula

C14H11ClN4S2

Molecular Weight

334.85

Precautions

H302, H315, H319, H335

References & Citations

[1]Takumi Naruse, et al. Novel ALK5 inhibitor TP0427736 reduces TGF-β induced growth inhibition in human outer root sheath cells and elongates anagen phase in mouse hair follicles. Pharmacol Rep. 2017 May;69 (3) :485-491.