DB1113

DB1113 (Example 24) is a bifunctional compound targeted protein degradation of kinases. DB1113 degrades ABL1, ABL2, BLK, CDK11B, CDK4, CSK, EPHA3, FER, GAK, LIMK1, MAP3K20, MAP4K1, MAP4K2, MAP4K3, MAP4K5, MAPK14, MAPK7, MAPK8, MAPK9, MAPKAPK2, MAPKAPK3, NLK, PDIK1L, PTK2B, RIPK1, RPS6KA1, RPS6KA3, SIK2, SIK3, STK35, TNK2, and ULK1. DB1113 can be used for research of disease or disorder mediated by aberrant kinase activity[1].

Product Specifications

CAS Number

[2769753-53-7]

UNSPSC

12352005

Target

Bcr-Abl; CDK; Cyclin G-associated Kinase (GAK) ; Ferroptosis; LIM Kinase (LIMK) ; MAP4K; MAPKAPK2 (MK2) ; PROTACs; Salt-inducible Kinase (SIK) ; ULK

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; PROTAC; Protein Tyrosine Kinase/RTK

Applications

COVID-19-anti-virus

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/db1113.html

Purity

99.86

Solubility

DMSO : 60 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC(NC(C3=CC(C(F)(F)F)=CC=C3)=O)=CC=C2C)CC4=CN=C(NC5=CN=C(N6CCN(CC6)CCCCC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(N[C@H](C8=CC=C(C9=C(N=CS9)C)C=C8)C)=O)=O)=O)C=C5)N=C4N1C

Molecular Formula

C59H68F3N13O6S

Molecular Weight

1144.31

References & Citations

[1]Gray Nathanael S, et al. Bifunctional compounds for targeted protein degradation of kinases: World Intellectual Property Organization, WO2022093742[P]. 2022-05-05.