BAR502

BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively.

Product Specifications

CAS Number

[1612191-86-2]

UNSPSC

12352211

Target

Autophagy; FXR; G protein-coupled Bile Acid Receptor 1

Type

Reference compound

Related Pathways

Autophagy; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/BAR502.html

Concentration

10mM

Purity

99.53

Solubility

DMF : 50 mg/mL (ultrasonic) |Ethanol : ≥ 50 mg/mL

Smiles

C[C@H](CCO)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)[C@H](CC)[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C

Molecular Formula

C25H44O3

Molecular Weight

392.62

References & Citations

[1]Festa C, et al. Exploitation of cholane scaffold for the discovery of potent and selective farnesoid X receptor (FXR) and G-protein coupled bile acid receptor 1 (GP-BAR1) ligands. J Med Chem. 2014 Oct 23;57 (20) :8477-95.|[2]Carino A, et al. BAR502, a dual FXR and GPBAR1 agonist, promotes browning of white adipose tissue and reverses liver steatosis and fibrosis. Sci Rep. 2017 Feb 16;7:42801.|[3]Cipriani S, et al. Impaired Itching Perception in Murine Models of Cholestasis Is Supported by Dysregulation of GPBAR1 Signaling. PLoS One. 2015 Jul 15;10 (7) :e0129866.