Berotralstat (Standard)
Berotralstat (Standard) is the analytical standard of Berotralstat. This product is intended for research and analytical applications. Berotralstat (BCX7353) is an orally active plasma kallikrein inhibitor. Berotralstat can reduce brain edema and is being studied for glioblastoma and hereditary angioedema.
Product Specifications
CAS Number
1809010-50-1
Product Name Alternative
BCX7353 (Standard)
UNSPSC
12352005
Target
Reference Standards; Ser/Thr Protease
Type
Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/berotralstat-standard.html
Smiles
O=C(C1=CC(C(F)(F)F)=NN1C2=CC(CN)=CC=C2)NC3=CC([C@@H](C4=CC(C#N)=CC=C4)NCC5CC5)=CC=C3F
Molecular Formula
C30H26F4N6O
Molecular Weight
562.56
References & Citations
[1]Zuraw B, et al. Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial [published online ahead of print, 2020 Oct 21]. J Allergy Clin Immunol. 2020; S0091-6749 (20) 31484-6.|[2]Manning ME, et al. Berotralstat (BCX7353) is a novel oral prophylactic treatment for hereditary angioedema: Review of phase II and III studies. Allergy Asthma Proc. 2021;42 (4) :274-282.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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