Phosphodiesterase-IN-2
Phosphodiesterase-IN-2 (Compound C7) is a selective, orally active inhibitor for phosphodiesterase 10A (PDE10A), with an IC50 of 11.9 nM. Phosphodiesterase-IN-2 improves the stability of liver microsomes, and lowers BBB permeability. Phosphodiesterase-IN-2 exhibits good pharmacokinetic characters, and attenuates isoprenaline -induced cardiac hypertrophic in mouse models[1].
Product Specifications
CAS Number
3047610-96-5
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/phosphodiesterase-in-2.html
Solubility
10 mM in DMSO
Smiles
FC(F)(F)C(C=C1C2=CC(C)=NC=C2)=NN1C3=CC=C(OCC4=NC5=C(C=CC=C5)C(C(N6CC7(CNC7)C6)=O)=C4)C=C3
Molecular Formula
C32H27F3N6O2
Molecular Weight
584.59
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE10
Frequently Asked Questions
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