(-) -Asarinin
(-) -Asarinin is a tetrahydrofurofurano lignan with various biological activities. (-) -Asarinin induces apoptosis in cancer cells. (-) -Asarinin promotes mitochondrial ROS accumulation, inhibits the STAT3 signaling pathway and induces apoptosis in precancerous cells. (-) -Asarinin is a Src family kinase inhibitor that suppresses mast cell activation. (-) -Asarinin is a non-competitive Δ5-desaturase inhibitor with a Ki of 0.28 mM. (-) -Asarinin possesses pain relief, anti-viral, anti-allergic and anti-tuberculous bacilli, and anti-tumor effects[1][2][3][4].
Product Specifications
CAS Number
133-04-0
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Bacterial; Reactive Oxygen Species (ROS) ; Src; STAT; Stearoyl-CoA Desaturase (SCD)
Type
Natural Products
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/asarinin.html
Purity
99.90
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H][C@]12[C@](CO[C@@H]2C3=CC=C(OCO4)C4=C3)([H])[C@H](C5=CC=C(OCO6)C6=C5)OC1
Molecular Formula
C20H18O6
Molecular Weight
354.35
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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