(S) - (+) -Rolipram
(S) - (+) -Rolipram ((+) -Rolipram) is a cyclic AMP (cAMP) -specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S) - (+) -Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3].
Product Specifications
CAS Number
85416-73-5
Product Name Alternative
(+) -Rolipram; (S) -Rolipram
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/_S_-__addition__-Rolipram.html
Concentration
10mM
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC[C@H](C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Molecular Formula
C16H21NO3
Molecular Weight
275.35
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE4
Available Sizes
Frequently Asked Questions
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