SPL-707
SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM) . SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells[1].
Product Specifications
CAS Number
2195361-33-0
UNSPSC
12352005
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/SPL-707.html
Purity
99.64
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC1=C(NC(C[C@@H](C2CC2)C(N[C@@H]3C(N(CC4(CC4)C5)N5C(C6=C3C=CC=C6)=O)=O)=O)=O)C=C(F)C=N1
Molecular Formula
C27H28FN5O4
Molecular Weight
505.54
References & Citations
[1]Velcicky J, et al. Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem. 2018 Feb 8;61 (3) :865-880.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042978-100 1x 100 µL
Cyclin B1 (G2- & M-phase Cyclin) (CCNB1/2978R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details 
BNC471485-500 1x 500 µL
DOG-1 / TMEM16A (Gastrointestinal Stromal Tumor Marker) (DG1/1485), CF647 conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![FAM131C Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI6G2]](https://cdn.genprice.uk/products/937/6868c409994c49e6dc404b31/imageurl/ta810783bm.webp)
TA810783BM 100 µL
FAM131C Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI6G2]
Sign In for Pricing
View Details 