SPL-707

SPL-707 is an orally active, selective signal peptide peptidase-like 2a (SPPL2a) inhibitor with an IC50 of 77 nM for hSPPL2a. SPL-707 inhibits γ-secretase (IC50=6.1 μM) and SPP (IC50=3.7 μM) . SPL-707 has the potential for autoimmune diseases research by targeting B cells and dendritic cells[1].

Product Specifications

CAS Number

[2195361-33-0]

UNSPSC

12352005

Target

γ-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/SPL-707.html

Purity

99.64

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC1=C(NC(C[C@@H](C2CC2)C(N[C@@H]3C(N(CC4(CC4)C5)N5C(C6=C3C=CC=C6)=O)=O)=O)=O)C=C(F)C=N1

Molecular Formula

C27H28FN5O4

Molecular Weight

505.54

References & Citations

[1]Velcicky J, et al. Discovery of the First Potent, Selective, and Orally Bioavailable Signal Peptide Peptidase-Like 2a (SPPL2a) Inhibitor Displaying Pronounced Immunomodulatory Effects In Vivo. J Med Chem. 2018 Feb 8;61 (3) :865-880.