α-Amyrin
Product Specifications
UNSPSC Description
α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can be used in the study of metabolic syndrome induced by high fructose diet and cognitive dysfunction caused by low cholinergic neurotransmission[1][2][3].
Target Antigen
ERK; GSK-3
Type
Natural Products
Related Pathways
MAPK/ERK Pathway;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Metabolic Disease; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/α-amyrin.html
Purity
99.94
Solubility
10 mM in DMSO|Methanol : 1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C
Molecular Weight
426.72
References & Citations
[1]Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99(9):935-942.|[2]Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42(1):23-32.|[3]Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37(7):1207-13.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-N8423/α-Amyrin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-N8423/α-Amyrin-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
638-95-9
Available Sizes
Curated Selection
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