α-Amyrin

α-Amyrin is a pentacyclic triterpenoid compound with oral activity. α-Amyrin activates the ERK and GSK-3β signaling pathways. α-Amyrin can inhibit cancer cells proliferation and induce apoptosis. α-Amyrin shows anti-bacterial and anti-inflammation activity. α-Amyrin can reduce blood glucose level. α-Amyrin can be used for the researches of cancer, infection, inflammation, metabolic disease and neurological disease, such as breast cancer, Streptococcus oralis infection, skin inflammation and diabetes[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[638-95-9]

UNSPSC

12352211

Hazard Statement

H302

Target

Apoptosis; Caspase; COX; ERK; GSK-3

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/α-amyrin.html

Purity

99.99

Solubility

DMSO : 5 mg/mL (ultrasonic)

Smiles

C[C@]12[C@]3(C([C@@]4([H])[C@@](CC3)(CC[C@H]([C@@H]4C)C)C)=CC[C@]1([H])[C@@]5([C@@](C(C)([C@H](CC5)O)C)([H])CC2)C)C

Molecular Formula

C30H50O

Molecular Weight

426.72

Precautions

H302

References & Citations

[1]Giacoman-Martínez A, et al. α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts. Can J Physiol Pharmacol. 2021 Sep;99 (9) :935-942.|[2]Prabhakar P, et al. α-Amyrin attenuates high fructose diet-induced metabolic syndrome in rats. Appl Physiol Nutr Metab. 2017 Jan;42 (1) :23-32.|[3]Park SJ, et al. Amyrin attenuates scopolamine-induced cognitive impairment in mice. Biol Pharm Bull. 2014;37 (7) :1207-13.|[4]Singh AB, et al. Antihyperglycaemic activity of alpha-amyrin acetate in rats and db/db mice. Nat Prod Res. 2009;23 (9) :876-82.|[5]Medeiros R, et al. Mechanisms underlying the inhibitory actions of the pentacyclic triterpene alpha-amyrin in the mouse skin inflammation induced by phorbol ester 12-O-tetradecanoylphorbol-13-acetate. Eur J Pharmacol. 2007 Mar 22;559 (2-3) :227-35.|[6]Kevine Kamga Silihe, Purification of α-amyrin-acetate and phenylpropanoïd compounds from Ficus umbellata Vahl (Moraceae) stem bark and evaluation of their anti-breast cancer potential, South African Journal of Botany, 177 (2025) 445-456.|[7]Díaz-Ruiz G, et al. Growth inhibition of Streptococcus from the oral cavity by α-amyrin esters. Molecules. 2012 Oct 25;17 (11) :12603-11.