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(S, R, S) -AHPC-PEG4-NH2

(S, R, S) -AHPC-PEG4-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and 4-unit PEG linker used in PROTAC technology.

Product Specifications

CAS Number

[2010159-57-4]

Product Name Alternative

VH032-PEG4-NH2; VHL Ligand-Linker Conjugates 4 ; E3 ligase Ligand-Linker Conjugates 7 Free Base

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/E3_ligase_Ligand-Linker_Conjugates_7_Free_Base.html

Purity

99.51

Solubility

DMSO : 170 mg/mL (ultrasonic)

Smiles

O=C(N[C@@H](C(C)(C)C)C(N(C[C@H](O)C1)[C@@H]1C(NCC2=CC=C(C(SC=N3)=C3C)C=C2)=O)=O)COCCOCCOCCOCCN

Molecular Formula

C32H49N5O8S

Molecular Weight

663.83

Precautions

H302, H315, H319, H335

References & Citations

[1]Crew, Andrew P, et al. MDM2-BASED MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. US20170008904A1.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Von Hippel-Lindau (VHL)

Available Sizes

Curated Selection

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