Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Alogliptin (Benzoate)

Alogliptin Benzoate (SYR-322) is a potent, selective and orally active inhibitor of DPP-4 with an IC50 of [1][2][3].

Product Specifications

CAS Number

850649-62-6

Product Name Alternative

SYR 322

UNSPSC

12352005

Hazard Statement

H302, H312, H332

Target

Dipeptidyl Peptidase; Ferroptosis

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/alogliptin-benzoate.html

Purity

99.98

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 14.29 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C=C(N1C[C@H](N)CCC1)N(C2=O)CC3=C(C#N)C=CC=C3)N2C.O=C(O)C4=CC=CC=C4

Molecular Formula

C25H27N5O4

Molecular Weight

461.51

Precautions

H302, H312, H332

References & Citations

[1]Feng J, et, al. Discovery of alogliptin: a potent, selective, bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem. 2007 May 17;50 (10) :2297-300.|[2]Ta NN, et, al. DPP-4 (CD26) inhibitor alogliptin inhibits TLR4-mediated ERK activation and ERK-dependent MMP-1 expression by U937 histiocytes. Atherosclerosis. 2010 Dec;213 (2) :429-35.|[3]Hao FL, et, al. The neurovascular protective effect of alogliptin in murine MCAO model and brain endothelial cells. Biomed Pharmacother. 2019 Jan;109:181-187.|[4]Asakawa T, et, al. A novel dipeptidyl peptidase-4 inhibitor, alogliptin (SYR-322), is effective in diabetic rats with sulfonylurea-induced secondary failure. Life Sci. 2009 Jul 17;85 (3-4) :122-6.|[5]Moritoh Y, et al. The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice. Eur J Pharmacol. 2009 Jan 14;602 (2-3) :448-54.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

DPP-4

Citation 01

Biochem Biophys Res Commun. 2019 Apr 2;511 (2) :387-393. |Biol Chem. 2023 Jan 12;404 (6) :633-643.|Chromatography. 2015,36 (1) :19-24.|Research Square Preprint. 2025 Jan 08.|Sci Rep. 2019 Dec 2;9 (1) :18094.|Sci Signal. 2023 Jan 17;16 (768) :eabh1083.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Recombinant PTBP2 Antibody
RC-15350-01 50 μL

Recombinant PTBP2 Antibody

Sign In for Pricing
View Details
Recombinant PTBP2 Antibody
RC-15350-02 100 µL

Recombinant PTBP2 Antibody

Sign In for Pricing
View Details
Recombinant PTBP2 Antibody
RC-15350-03 1 mL

Recombinant PTBP2 Antibody

Sign In for Pricing
View Details
Cre recombinase Recombinant Rabbit monoclonal Antibody
HA750767 100 µL

Cre recombinase Recombinant Rabbit monoclonal Antibody

Sign In for Pricing
View Details
CD40 / TNFRSF5 / CD40L-Receptor (C40/2383), Biotin conjugate, 0.1mg/mL
BNCB2383-100 1x 100 µL

CD40 / TNFRSF5 / CD40L-Receptor (C40/2383), Biotin conjugate, 0.1mg/mL

Sign In for Pricing
View Details
Uaca Mouse Gene Knockout Kit (CRISPR)
KN518539 1 Kit

Uaca Mouse Gene Knockout Kit (CRISPR)

Sign In for Pricing
View Details