MK-8153
MK-8153 is a potent, selective and orally active inhibitor of renal outer medullary potassium channel (ROMK), with IC50s of 5 nM, 34 μM for ROMK electrophysiology (EP) and hERG EP, respectively. MK-8153 can be used as the diuretic/atriuretic[1].
Product Specifications
CAS Number
[1548286-45-8]
UNSPSC
12352005
Hazard Statement
H315-H319-H320
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/mk-8153.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C2=C(C)C(OC2)=O)CCC13CCN(C[C@@H](C4=C(C)C5=C(C(OC5)=O)C=C4)O)CC3
Molecular Formula
C24H28N2O6
Molecular Weight
440.49
Precautions
P264-P280-P302+P352-P305+P351+P338-P362
References & Citations
[1]Jiang J, et, al. Discovery of MK-8153, a Potent and Selective ROMK Inhibitor and Novel Diuretic/Natriuretic. J Med Chem. 2021 May 26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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