GSK-3β inhibitor 11
GSK-3β inhibitor 11 (compound 21) is a glycogen synthase kinase-3β (GSK-3β) inhibitor (IC50=10.02 μM) . GSK-3β inhibitor 11 can be used in neurodegenerative disease research[1].
Product Specifications
CAS Number
[536731-65-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
GSK-3
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3β-inhibitor-11.html
Purity
98.02
Solubility
DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=C(C(N1CC(NC3=NC(C4=CC(OC)=CC=C4)=CS3)=O)=O)C=CC=C2
Molecular Formula
C20H15N3O4S
Molecular Weight
393.42
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Fu G, et al. Pharmacophore Modeling, Ensemble Docking, Virtual Screening, and Biological Evaluation on Glycogen Synthase Kinase-3β. Mol Inform. 2014 Sep;33 (9) :610-26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GSK-3β
Available Sizes
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