Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

IFN-alpha/beta R2, Human (HEK293, hFc)

IFN-alpha/beta R2, one of the subunit of IFN-α/β receptor, is a type I IFN receptor. IFN-alpha/beta R2 forms the heterodimeric receptor with IFNAR1, and binds to type I IFNs[1]. IFN-alpha/beta R2 also interacts with JAK1 and leads to tyrosine phosphorylation of the IFNARs and STAT proteins[2]. Upon activation by these IFNs, IFNAR1 and IFN-alpha/beta R2 undergo a conformational change to promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, STAT1 and STAT2[3]. IFN-alpha/beta R2 Protein, Human (HEK293, hFc) is a recombinant human IFN-alpha/beta R2 (I27-K243) with C-terminal hFc tag, which is produced in HEK293 cells.

Product Specifications

Product Name Alternative

IFN-alpha/beta R2 Protein, Human (HEK293, hFc), Human, HEK293

UNSPSC

12352202

Type

Recombinant Proteins

Assay Protocol

https://www.medchemexpress.com/cytokines/ifn-alpha-beta-r2-protein-human-hek293-hfc.html

Purity

96.0

Molecular Formula

3455 (Gene_ID) P48551-1 (I27-K243) (Accession)

Molecular Weight

65-75 kDa

References & Citations

[1]Zanin N, et al. Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads. Front Immunol. 2021 Jan 20;11:615603.|[2]Shemesh M, et al. IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Sci Signal. 2021 Nov 23;14 (710) :eabe4627. |[3]Jun Zou, et al. Chapter 7 - Antiviral Immunity: Origin and Evolution in Vertebrates. The Evolution of the Immune System. 2016, Pages 173-204.|[4]Pogue SL, et al. The receptor for type I IFNs is highly expressed on peripheral blood B cells and monocytes and mediates a distinct profile of differentiation and activation of these cells. J Interferon Cytokine Res. 2004 Feb;24 (2) :131-9.|[5]Duncan CJ, et al. Human IFNAR2 deficiency: Lessons for antiviral immunity. Sci Transl Med. 2015 Sep 30;7 (307) :307ra154.|[6]Hurtado-Guerrero I, et al. Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-β Mediation. J Clin Med. 2020 Mar 31;9 (4) :959.

Shipping Conditions

Dry ice

Storage Conditions

Stored at -80°C for 1 year

Scientific Category

Recombinant Proteins

Available Sizes

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

SCN-09-D ClipSleeve Markers
133163 300 Pack (30 Sleeve (s) x 10 Wand)

SCN-09-D ClipSleeve Markers

Ask
View Details
HLA-DMA (HLA Class II Histocompatibility Antigen, DM alpha Chain, MHC Class II Antigen DMA, Really Interesting New Gene 6 Protein, DMA, RING6) (MaxLight 750)
MBS6381230-01 0.1 mL

HLA-DMA (HLA Class II Histocompatibility Antigen, DM alpha Chain, MHC Class II Antigen DMA, Really Interesting New Gene 6 Protein, DMA, RING6) (MaxLight 750)

Ask
View Details
HLA-DMA (HLA Class II Histocompatibility Antigen, DM alpha Chain, MHC Class II Antigen DMA, Really Interesting New Gene 6 Protein, DMA, RING6) (MaxLight 750)
MBS6381230-02 5x 0.1 mL

HLA-DMA (HLA Class II Histocompatibility Antigen, DM alpha Chain, MHC Class II Antigen DMA, Really Interesting New Gene 6 Protein, DMA, RING6) (MaxLight 750)

Ask
View Details
GAL3 (Galectin 3) Sheep ELISA Kit
D5763 96 Tests

GAL3 (Galectin 3) Sheep ELISA Kit

Ask
View Details
CD117 Rabbit Polyclonal Antibody
TA377824 100 µL

CD117 Rabbit Polyclonal Antibody

Ask
View Details
DEFA1 Human Pre-designed siRNA Set A
HY-RS03673 1 Set

DEFA1 Human Pre-designed siRNA Set A

Ask
View Details