Aluminum Hydroxide

Aluminum Hydroxide is an orally active main form of aluminum used as adjuvant. Aluminum hydroxide-based adjuvant researches include the repository effect, pro-phagocytic effect, and activation of the pro-inflammatory NLRP3 pathway. Aluminum Hydroxide also acts as adjuvant to compensate low inherent immunogenicity of subunit vaccines[1][2].

Product Specifications

CAS Number

[21645-51-2]

UNSPSC

12352300

Hazard Statement

H319

Target

NOD-like Receptor (NLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/aluminum-hydroxide.html

Purity

97.0

Solubility

DMSO : < 1 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O[Al](O)O

Molecular Formula

AlH3O3

Molecular Weight

78.00

Precautions

H319

References & Citations

[1]He P, et al. Advances in aluminum hydroxide-based adjuvant research and its mechanism. Hum Vaccin Immunother. 2015;11 (2) :477-88.|[2]Amini Y, et al. Aluminum hydroxide nanoparticles show strong activity to stimulate Th-1 immune response against tuberculosis. Artif Cells Nanomed Biotechnol. 2017 Nov;45 (7) :1331-1335.|[3]Ohtawa M, et al. Effect of aluminum ingestion on lipid peroxidation in rats. Chem Pharm Bull (Tokyo) . 1983 Apr;31 (4) :1415-8.