ML-SA1

ML-SA1, as a selective TRPML agonist, inhibits Dengue virus 2 (DENV2) and Zika virus (ZIKV) by promoting lysosomal acidification and protease activity. The IC50 value of ML-SA1 against DENV2 RNA and ZIKV RNA is 8.3 μM and 52.99 μM, respectively. ML-SA1 induces autophagy. ML-SA1 can be used for the research of broad-spectrum antiviral[1].

Product Specifications

CAS Number

[332382-54-4]

UNSPSC

12352005

Hazard Statement

H301, H410

Target

Dengue Virus; Flavivirus; TRP Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ml-sa1.html

Purity

99.44

Solubility

DMSO : 20.83 mg/mL (ultrasonic; warming; heat to 65°C)

Smiles

O=C1N(CC(N2C(C)(C)CC(C)C3=C2C=CC=C3)=O)C(C4=C1C=CC=C4)=O

Molecular Formula

C22H22N2O3

Molecular Weight

362.42

Precautions

H301, H410

References & Citations

[1]Xia Z, et al. ML-SA1, a selective TRPML agonist, inhibits DENV2 and ZIKV by promoting lysosomal acidification and protease activity. Antiviral Res. 2020;182:104922.