Inauhzin

Inauhzin is a dual SirT1/IMPDH2 inhibitor, and acts as an activator p53, used in the research of cancer.

Product Specifications

CAS Number

[309271-94-1]

Product Name Alternative

INZ

UNSPSC

12352005

Hazard Statement

H302, H317

Target

MDM-2/p53; Sirtuin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Inauhzin.html

Purity

98.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCC(SC1=NN=C2C(NC3=C2C=CC=C3)=N1)C(N4C5=C(C=CC=C5)SC6=CC=CC=C46)=O

Molecular Formula

C25H19N5OS2

Molecular Weight

469.58

Precautions

H302, H317

References & Citations

[1]Zhang Q, et al. A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53. EMBO Mol Med. 2012 Apr;4 (4) :298-312.|[2]Zhang Y, et al. Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth. Cancer Biol Ther. 2012 Aug;13 (10) :915-24.|[3]Nguyen D, et al. Reviving the guardian of the genome: Small molecule activators of p53. Pharmacol Ther. 2017 Oct;178:92-108.