Duloxetine
Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) [1][2].
Product Specifications
CAS Number
[116539-59-4]
Product Name Alternative
LY248686
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Serotonin Transporter
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/duloxetine.html
Purity
99.92
Solubility
10 mM in DMSO
Smiles
CNCC[C@H](OC1=CC=CC2=C1C=CC=C2)C3=CC=CS3
Molecular Formula
C18H19NOS
Molecular Weight
297.41
Precautions
H302, H315, H319, H335
References & Citations
[1]De Berardis, D., et al., The effect of newer serotonin-noradrenalin antidepressants on cytokine production: a review of the current literature. Int J Immunopathol Pharmacol, 2010. 23 (2) : p. 417-22.|[2]Wang, S.Y., J. Calderon, and G. Kuo Wang, Block of neuronal Na+ channels by antidepressant duloxetine in a state-dependent manner. Anesthesiology, 2010. 113 (3) : p. 655-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell. 2025 Oct 24:S0092-8674 (25) 01131-6.|Mol Brain. 2025 Apr 4;18 (1) :29.|Neurosci Lett. 2022 Mar 16;773:136512.|Phytomedicine. 2025 Sep:145:157039.|Autism Res. 2022 Jan;15 (1) :27-41.|Eur J Pharmacol. 2025 Jun 15:997:177476.|Neurotox Res. 2020 Dec;38 (4) :859-870.|Patent. US20250002569A1.|Università Vita-Salute San Raffaele. 2022 Apr 08. 34.
Available Sizes
Curated Selection
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