Syk-IN-4

Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers[1].

Product Specifications

CAS Number

[2932264-95-2]

UNSPSC

12352005

Target

Syk

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/syk-in-4.html

Concentration

10mM

Purity

98.0

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

CC1=NN(C=C1CN(C)C)C2=NC(NC3=CC=C(N(C)N=C4C(NC)=O)C4=C3)=NC=C2

Molecular Formula

C21H25N9O

Molecular Weight

419.48

References & Citations

[1]Neil P Grimster, et al. Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors. Bioorg Med Chem Lett. 2020 Jul 24;127433.