Syk-IN-4
Product Specifications
UNSPSC Description
Syk-IN-4 is a potent, selective and orally bioavailable SYK inhibitor with an IC50 of 0.31 nM. SYK has emerged as a potential target for autoimmunity and hematological cancers[1].
Target Antigen
Syk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/syk-in-4.html
Purity
98.0
Solubility
DMSO : 62.5 mg/mL (ultrasonic)
Smiles
CC1=NN(C=C1CN(C)C)C2=NC(NC3=CC=C(N(C)N=C4C(NC)=O)C4=C3)=NC=C2
Molecular Weight
419.48
References & Citations
[1]Neil P Grimster, et al. Optimization of a Series of Potent, Selective and Orally Bioavailable SYK Inhibitors. Bioorg Med Chem Lett. 2020 Jul 24;127433.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131341/Syk-IN-4-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131341/Syk-IN-4-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2932264-95-2
Available Sizes
Curated Selection
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