Cortistatin 14 (mouse, rat)
Product Specifications
UNSPSC Description
Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].
Target Antigen
Somatostatin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/cortistatin-14-human-rat.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
[H]N1CCC[C@H]1C(N[C@H]2CSSC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CCCCN)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC5=CNC6=C5C=CC=C6)=O)CCCCN)=O)=O)CC7=CC=CC=C7)=O)CO)=O)CO)=O)=O
Molecular Weight
1721.01
References & Citations
[1]Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767.|[2]de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381(6579):242-5.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P1212/Cortistatin-14-mouse-rat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P1212/Cortistatin-14-mouse-rat-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
193829-96-8
Available Sizes
Curated Selection
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