Cortistatin 14 (mouse, rat)

Cortistatin 14, mouse, rat (CST-14, human, rat), a neuropeptide with neuronal depressant and sleep modulating properties, can bind to all five cloned somatostatin receptors (SSTRs) and ghrelin receptor to exert its biological activities and co-exists with GABA within the cortex and hippocampus[1][2].

Product Specifications

CAS Number

[193829-96-8]

Product Name Alternative

CST-14 (mouse, rat)

UNSPSC

12352209

Target

Somatostatin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/cortistatin-14-human-rat.html

Purity

99.45

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[H]N1CCC[C@H]1C(N[C@H]2CSSC[C@@H](C(N[C@H](C(O)=O)CCCCN)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@H](O)C)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC2=O)CCCCN)=O)CC(N)=O)=O)CC3=CC=CC=C3)=O)CC4=CC=CC=C4)=O)CC5=CNC6=C5C=CC=C6)=O)CCCCN)=O)=O)CC7=CC=CC=C7)=O)CO)=O)CO)=O)=O

Molecular Formula

C81H113N19O19S2

Molecular Weight

1721.01

References & Citations

[1]Jiang J, et al. Centrally Administered Cortistation-14 Induces Antidepressant-Like Effects in Mice via MediatingGhrelin and GABAA Receptor Signaling Pathway. Front Pharmacol. 2018 Jul 19;9:767.|[2]de Lecea L, et al. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. Nature. 1996 May 16;381 (6579) :242-5.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

Scientific Category

Peptides

Clinical Information

No Development Reported

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