Sec61-IN-1
Sec61-IN-1 (compound A317) is a potent sec61 inhibitor that effectively targets glioma cells and enhances T cell cytotoxic effects[1][2].
Product Specifications
CAS Number
[2484865-42-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Sec61
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sec61-in-1.html
Purity
99.70
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=CN1CC2=CC=NC=C2)NC3=NC([C@@H]4N(C5=NC=CC=C5)CCC4)=CS3
Molecular Formula
C23H22N6OS
Molecular Weight
430.53
Precautions
H302, H315, H319, H335
References & Citations
[1]Dustin Mcminn, et al. Thiazole derivatives as protein secretion inhibitors. WO2020176863A1.|[2]Methods for sensitizing glioma cells to immunotherapy with a Sec61 complex inhibitor. United States, US20250099449 A1 2025-03-27.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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