Kukoamine A
Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Product Specifications
CAS Number
[75288-96-9]
UNSPSC
12352005
Target
Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/kukoamine-a.html
Purity
99.88
Solubility
DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)
Smiles
O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2
Molecular Formula
C28H42N4O6
Molecular Weight
530.66
References & Citations
[1]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 (Pt 2) :371-5.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Trypanosoma
Available Sizes
Curated Selection
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