Kukoamine A

Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

Product Specifications

CAS Number

[75288-96-9]

UNSPSC

12352005

Target

Parasite

Type

Natural Products

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/kukoamine-a.html

Purity

99.88

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCCNCCCCNCCCNC(CCC1=CC=C(O)C(O)=C1)=O)CCC2=CC=C(O)C(O)=C2

Molecular Formula

C28H42N4O6

Molecular Weight

530.66

References & Citations

[1]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 (Pt 2) :371-5.