Guanidine (hydrochloride)

Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].

Product Specifications

CAS Number

[50-01-1]

Product Name Alternative

Guanidinium (chloride) ; Aminoformamidine (hydrochloride)

UNSPSC

12352211

Hazard Statement

H302+H332, H315, H319, H402

Target

Autophagy; Endogenous Metabolite

Type

Natural Products

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/guanidine-hydrochloride.html

Purity

99.9

Solubility

DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

NC(N)=N.Cl

Molecular Formula

CH6ClN3

Molecular Weight

95.53

Precautions

H302+H332, H315, H319, H402

References & Citations

[1]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231 (2) :180-4.|[2]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43 (1) :7-10.|[3]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450 (4) :1339-44.|[4]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2 (6) :339-46.