Guanidine (hydrochloride)
Guanidine hydrochloride (Guanidinium chloride) a strong chaotrope, is also a strong denaturant of proteins[1][2].
Product Specifications
CAS Number
50-01-1
Product Name Alternative
Guanidinium (chloride) ; Aminoformamidine (hydrochloride)
UNSPSC
12352211
Hazard Statement
H302+H332, H315, H319, H402
Target
Autophagy; Endogenous Metabolite
Type
Natural Products
Related Pathways
Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/guanidine-hydrochloride.html
Purity
99.9
Solubility
DMSO : ≥ 100 mg/mL|H2O : 100 mg/mL (ultrasonic)
Smiles
NC(N)=N.Cl
Molecular Formula
CH6ClN3
Molecular Weight
95.53
Precautions
H302+H332, H315, H319, H402
References & Citations
[1]Y Hagihara, et al. Guanidine hydrochloride-induced folding of proteins. J Mol Biol. 1993 May 20;231 (2) :180-4.|[2]G Jung, et al. Guanidine hydrochloride inhibits Hsp104 activity in vivo: a possible explanation for its effect in curing yeast prions. Curr Microbiol. 2001 Jul;43 (1) :7-10.|[3]Saeed Emadi, et al. A comparative study on the aggregating effects of guanidine thiocyanate, guanidine hydrochloride and urea on lysozyme aggregation. Biochem Biophys Res Commun. 2014 Aug 8;450 (4) :1339-44.|[4]E C Herrmann Jr, et al. Prevention of death in mice infected with coxsackievirus A16 using guanidine HCl mixed with substituted benzimidazoles. Antiviral Res. 1982 Dec;2 (6) :339-46.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Natural Products
Clinical Information
Launched
Isoform
Human Endogenous Metabolite
Available Sizes
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