Chlorothalonil

Chlorothalonil is a broad-spectrum foliar fungicide with oral activity. Chlorothalonil can be used to combat fungal diseases in vegetable and crop leaves. Chlorothalonil can alter the microbial community in the soil. Chlorothalonil inhibits spermatogenesis. Chlorothalonil can cause intestinal epithelial barrier dysfunction and fetal toxicity[1][2][3][4][5].

Product Specifications

CAS Number

[1897-45-6]

UNSPSC

12352005

Hazard Statement

H317, H318, H330, H335, H351, H410

Target

Estrogen Receptor/ERR; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Vitamin D Related/Nuclear Receptor

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/chlorothalonil.html

Concentration

10mM

Purity

98.15

Solubility

DMSO : 33.33 mg/mL (ultrasonic)

Smiles

N#CC1=C(Cl)C(Cl)=C(Cl)C(C#N)=C1Cl

Molecular Formula

C8Cl4N2

Molecular Weight

265.91

Precautions

H317, H318, H330, H335, H351, H410

References & Citations

[1]Farag A T, et al. Embryotoxicity of oral administered chlorothalonil in mice[J]. Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2006, 77 (2) : 104-109.|[2]Sigler W V, et al. The impact of chlorothalonil application on soil bacterial and fungal populations as assessed by denaturing gradient gel electrophoresis[J]. Applied Soil Ecology, 2002, 21 (2) : 107-118.|[3]Singh BK, et al. Degradation of chlorpyrifos, fenamiphos, and chlorothalonil alone and in combination and their effects on soil microbial activity. Environ Toxicol Chem. 2002 Dec;21 (12) :2600-5. PMID: 12463554.|[4]Tao H, et al. Chlorothalonil induces the intestinal epithelial barrier dysfunction in Caco-2 cell-based in vitro monolayer model by activating MAPK pathway. Acta Biochim Biophys Sin (Shanghai) . 2021 Nov 10;53 (11) :1459-1468. |[5]Zhang P, et al. Low dose chlorothalonil impairs mouse spermatogenesis through the intertwining of Estrogen Receptor Pathways with histone and DNA methylation. Chemosphere. 2019 Sep;230:384-395.