TCS JNK 5a

TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.

Product Specifications

CAS Number

[312917-14-9]

Product Name Alternative

JNK Inhibitor IX

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; JNK

Type

Reference compound

Related Pathways

Apoptosis; MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/TCS-JNK-5a.html

Purity

99.40

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

O=C(C1=C2C=CC=CC2=CC=C1)NC3=C(C#N)C(CCCC4)=C4S3

Molecular Formula

C20H16N2OS

Molecular Weight

332.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Angell RM, et al. N- (3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl) amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1296-301.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

JNK2; JNK3

Available Sizes

Curated Selection

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