TCS JNK 5a
TCS JNK 5a is a potent JNK3 inhibitor with a pIC50 of 6.7. TCS JNK 5a also inhibits JNK2 with a pIC50 of 6.5.
Product Specifications
CAS Number
[312917-14-9]
Product Name Alternative
JNK Inhibitor IX
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; JNK
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/TCS-JNK-5a.html
Purity
99.40
Solubility
DMSO : 20 mg/mL (ultrasonic)
Smiles
O=C(C1=C2C=CC=CC2=CC=C1)NC3=C(C#N)C(CCCC4)=C4S3
Molecular Formula
C20H16N2OS
Molecular Weight
332.42
Precautions
H302, H315, H319, H335
References & Citations
[1]Angell RM, et al. N- (3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl) amides as potent, selective, inhibitors of JNK2 and JNK3. Bioorg Med Chem Lett. 2007 Mar 1;17 (5) :1296-301.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JNK2; JNK3
Available Sizes
Curated Selection
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