Silymarin

Silymarin is an extract of the milk thistle (Silybum marianum) . Silymarin is an effective SARS-CoV-2 main protease (Mpro) inhibitor. Silymarin can significantly reduce tumor cell proliferation, angiogenesis as well as insulin resistance. Silymarin has the chemopreventive effect on hepatocellular carcinoma (HCC) . Silymarin has the potential for COVID-19 research[1][2][4].

Product Specifications

CAS Number

[65666-07-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

SARS-CoV

Type

Natural Products

Related Pathways

Anti-infection

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/silymarin.html

Purity

82.50

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

[Silymarin]

Precautions

H302, H315, H319, H335

References & Citations

[1]Féher J, et al. Silymarin in the prevention and treatment of liver diseases and primary liver cancer. Curr Pharm Biotechnol. 2012 Jan;13 (1) :210-7.|[2]Sung-Hyun Kim, et al.Silymarin induces inhibition of growth and apoptosis through modulation of the MAPK signaling pathway in AGS human gastric cancer cells. Oncol Rep. 2019 Nov;42 (5) :1904-1914.|[3]Mina Khoshnoodi, et al. Possible involvement of nitric oxide in antidepressant-like effect of silymarin in male mice. Pharm Biol. 2015 May;53 (5) :739-45.|[4]Anna Maria Sardanelli, et al. SARS-CoV-2 Main Protease Active Site Ligands in the Human Metabolome. Molecules 2021, 26 (5), 1409.