Niclosamide
Niclosamide (BAY2353) is an orally active antihelminthic agent used in parasitic infection research[1]. Niclosamide is a STAT3 inhibitor with an IC50 of 0.25 μM in HeLa cells[4]. Niclosamide has biological activities against cancer, inhibits DNA replication in Vero E6 cells[2][3][5].
Product Specifications
CAS Number
50-65-7
Product Name Alternative
BAY2353
UNSPSC
12352005
Hazard Statement
H400
Target
Antibiotic; Parasite; STAT
Type
Reference compound
Related Pathways
Anti-infection; JAK/STAT Signaling; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cancer
Assay Protocol
https://www.medchemexpress.com/Niclosamide.html
Purity
99.96
Solubility
DMF : 5 mg/mL (ultrasonic) |DMSO : 4.55 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NC1=CC=C([N+]([O-])=O)C=C1Cl)C2=CC(Cl)=CC=C2O
Molecular Formula
C13H8Cl2N2O4
Molecular Weight
327.12
Precautions
H400
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
STAT3
Available Sizes
Frequently Asked Questions
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