Anticancer agent 211

Anticancer agent 211 (AK301) can inhibit tubulin polymerization. Anticancer agent 211 can block the division of human colon cancer cells. Anticancer agent 211 can increase the sensitivity of human colon cancer cells to apoptotic ligands and promote cell apoptosis[1].

Product Specifications

CAS Number

[314022-97-4]

UNSPSC

12352005

Target

Apoptosis; Microtubule/Tubulin

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-211.html

Smiles

ClC1=CC(N2CCN(CC2)C(C3=C(C=CC=C3)OCC)=O)=CC=C1

Molecular Formula

C19H21ClN2O2

Molecular Weight

344.84

References & Citations

[1]Chopra A, et al. Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis. J Biol Chem. 2014 Jan 31;289 (5) :2978-91.