Tenidap (sodium)
Tenidap is a non-steroidal anti-inflammatory active molecule and a selective inhibitor of COX-1, with IC50 values of 0.03 μM for COX-1 and 1.2 μM for COX-2. Tenidap exhibits anti-inflammatory and anti-rheumatic effects. Tenidap is a specific inhibitor of SLC26A3[1][2][3].
Product Specifications
CAS Number
119784-94-0
Product Name Alternative
CP-66248 (sodium)
UNSPSC
12352005
Target
COX
Type
Reference compound
Related Pathways
Immunology/Inflammation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tenidap-sodium.html
Smiles
O=C1/C(C2=CC(Cl)=CC=C2N1C(N)=O)=C(C3=CC=CS3)\O[Na]
Molecular Formula
C14H8ClN2NaO3S
Molecular Weight
342.73
References & Citations
[1]Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282 (2) :1094-101.|[2]Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38 (10) :1447-56.|[3]Chávez JC, et al. Participation of the Cl-/HCO (3) - exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. Biol Reprod. 2012 Jan 19;86 (1) :1-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-1; COX-2
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