Synucleozid (hydrochloride)

Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the SNCA mRNA that encodes α-synuclein protein. Synucleozid selectively targets the α-synuclein mRNA 5′ UTR at the designed IRE site, decreases the amount of SNCA mRNA loaded into polysomes and thereby inhibits SNCA translation. Synucleozid has the potential for the investigation of Parkinson’s disease[1].

Product Specifications

CAS Number

[2741856-68-6]

Product Name Alternative

NSC 377363 (hydrochloride)

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/synucleozid-hydrochloride.html

Concentration

10mM

Purity

98.23

Solubility

DMSO : 125 mg/mL (ultrasonic) |H2O : 2 mg/mL (ultrasonic)

Smiles

N=C(C1=CC2=C(C=C1)C=C(C3=CC=C(NC4=CC=C(C(N)=N)C=C4)C=C3)N2)N.Cl

Molecular Formula

C22H21ClN6

Molecular Weight

404.90

References & Citations

[1]Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117 (3) :1457-1467.